| Carl, Thanks for the question.  I would categorize people with gender dysphoria as mentally/emotionally ill.  Despite what the current trend and culture says, these people have a great internal struggle that has nothing to do with being born in the wrong body.  We must be compassionate and patient with these folks as they must suffer a great deal. What to call them is another problem.  You can say to a friend who wants to be called by a new name,  
                                                                                "I'm not comfortable with using a different gender name, when I'm not in agreement with altering your innate gender. 
                                                                                It would be important to stress that you love the person as a person regardless of their gender struggles, but you are never in favor of gender reversal when science and other disciplines have told us it is not a metaphysical issue but psychological one.
                                                                                     Can we agree to a gender neutral nickname that makes both you and I comfortable while you work this through?" Peace, Bob
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